Novel mechanisms of gliadin immunotoxicity?
نویسندگان
چکیده
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منابع مشابه
Molecular and Immunological Characterization of Gluten Proteins Isolated from Oat Cultivars That Differ in Toxicity for Celiac Disease
A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease (CD). Traditionally, treatment with a GFD has excluded wheat, barley and rye, while the presence of oats is a subject of debate. The most-recent research indicates that some cultivars of oats can be a safe part of a GFD. In order to elucidate the toxicity of the prolamins from ...
متن کاملSensitive detection of cereal fractions that are toxic to celiac disease patients by using monoclonal antibodies to a main immunogenic wheat peptide.
BACKGROUND Celiac disease is an immune-mediated enteropathy caused by the ingestion of gluten, a protein fraction found in certain cereals. Immunotoxic gluten peptides that are recalcitrant to degradation of digestive enzymes appear to trigger celiac syndromes. A 33-mer peptide from alpha-2 gliadin has been identified as a principal contributor to gluten immunotoxicity. A gluten-free diet is th...
متن کاملGene Expression Profiling of Gliadin Effects on Intestinal Epithelial Cells Suggests Novel Non-Enzymatic Functions of Pepsin and Trypsin
Gliadin triggers T-cell mediated immunity in celiac disease, and has cytotoxic effects on enterocytes mediated through obscure mechanisms. In addition, gliadin transport mechanisms, potential cell surface receptors and gliadin-activated downstream signaling pathways are not completely understood. In order to screen for novel downstream gliadin target genes we performed a systematic whole genome...
متن کاملIsolation and phylogenetic analysis of novel γ-gliadin genes in genus Dasypyrum.
As the most ancient member of the wheat gluten family, the γ-gliadin genes are suitable for phylogenetic analysis among wheat and related species. Species in the grass genus Dasypyrum have been widely used for wheat cross breeding. However, the genomic relationships among Dasypyrum species have been little studied. We isolated 22 novel γ-gliadin gene sequences, among which 10 are putatively fun...
متن کاملEffect of Propolis on Immunotoxicity Induced by Phenol Subchronic Use in Adult Albino Rats
Phenol is naturally found in some foods and animal wastes. It is also used as a disinfectant, insecticide and in some pharmaceutical products. Immunotoxicity is considered to be one of the harmful health effects of phenol. Propolis is a mixture of beeswax and resins; it has an antimicrobial, anti-inflammatory, antioxidant and immunomodulatory effect. This study investigates effect of propolis o...
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ورودعنوان ژورنال:
- Gut
دوره 59 3 شماره
صفحات -
تاریخ انتشار 2010